Experiencia inductiva con microdosis de rFsh, en pacientes con Síndrome de ovarios poliquísticos

Resumen

El (SOP) es una expresión metabólica que aparece durante la vida reproductiva.

Objetivo: Evaluar como marcador el Ca 125 sérico a partir del día + 20 pos (IIU), previo esquema con microdosis (MD) de rFSH. sin GnRHa. .

Material y Métodos En programas de baja complejidad se analizan 30 ciclos depurados de 147 pacientes (18.88%), que no recibieron tratamiento previo con inductores 6 meses antes del estudio, el (imc) ± de 25 kgs de mt2. con menotropinas normales en el 1er dia del ciclo, e inhibina ß.al 6 dia, con valores > 50pc. Con rFsh. 37.5 U cada 24 hs por 6 dias, El seguimiento folicular por via T/V con transductor de 7.5 MHz, se aplica la tabla de Bhal..Aplicándose rHGC +12 del ciclo( Dependiendo de resultados Lab y Eco).y. Al día + 17 se repiten E2 y P4 ( Predictivo de fertlización)y el día +20 ,se mide Ca 125 por el método de Elisa, (.habiendo descartando neoplasias, o signos de malignidad ). El plasma seminal se procesa con en el Analizador de Gases ABL.330 . previa licuefacción en su lectura de Ph. Y estudio morfológíco,

Comentarios y Resulados: .El método descrito en 1995 por Dick en pacientes con (SOP), e IMC de 26 kgs/ mt 2 en obvio de hiperestimulaciones, Se menciona la importancia de un intercambio paracrino y/o autocrino endometrial En 9 casos los niveles de Ca -125 > al día + 20, , fueron > 30 U. en el 60% durante la implantación. La implantación embrionaria en la especia humana es regulada por muchos factores, los cuales permiten el éxito de la misma, Se menciona la importancia de un intercambio paracrino y/o autocrino endometrial

Conclusiones El beneficio de MD de rFsh.Con el Ca-125,+ de 30U/ml a dia +20 fué del 60% (15/9). Como marcador durante la implantación.

Palabra Clave: Inhibina ß, Ca 125, Microdosis rFSH en OPQ.

Ernesto Gómez Arzapalo y V (1) "2" Clinica Florida Satelite. Victor Manuel Cerecedo Caballero"2" Alfredo Villacorta Argaez. 3" Hospital de Obstetricia y Pernatología Rio de la Loza Laboratorio – Métodos Diagnosticos

[email protected]

Inductive experience with rFsh microdosing in patients with Polycystic ovarían syndrome. Revition: Implantation evidence with CA-125 as match evaluation. In 9th cases.

Abstract: Polycystic ovarian syndrome (PCOS) is a metabolic expression that which becomes apparent during the reproductive stage.

Objective: To evaluate the behavior of serum as match CA-125 starting day +20 pos (IIU), before a stimulation scheme with rFSH microdosing without GnRHa.

Materials and methods: In low complexity programs 30 cycles purge,& analyzed. In an open population, from147 latino patients. were taken 18.88% did not receive steroids or ovulation induction treatment 6 months prior to the study, they showed body mass index (BMI) of ± 25 kg /m2 with normal Inhibin ß hormone serum levels on 6th cycle day. Menotropins at the first day of cycle were analyzed. 37.5 U of subdermal  rFSH were applied every 24 hours for 6 days. Follicles were followed with trasvaginal ultrasound using a 7.5 MHz trasductor showing pripheric follicular perfusion zones, classifying follicular perfusion according to Bhal"s  table from 1 to 4 with chromatic images of peripheral follicular perfusion, like the endometrium height and trilaminar endometrial imaging, applying rGCH on the 12th day of cycle( depend of results ). At the +17 day E2 and P4 are analyzed to evaluate fertilization. At day +20 CA-125 is measured using the Elisa method, considering + in >30U in 60% of the implantation processes (any neoplasia or maliganacy was discarded). The seminal plasma sieve was submitted to  gas analysis processed in the ABL.330 Radiometer 1990, wieyh a previous liquefaction of one hour for pH analysis and morphologic description.

Comments& Results: The method mriginally described by Dick in 1995, was mainly oriented to patients with PCOS, with BMI of 26 kg/m2 with obvious  hyperestimulation and endometrial and metabolic alterations. It is mentioned the great importance of the paracrine and/or autocrine endometrial exchange.

CA-125 levels rise at week ten and then diminish until partum. The embryonic implantation in human species is regulated by a lot and very important factors which allow it"s success in a 30% rate.

Conclussions: The inductive benefits with rFSH microdosing, tha utility of elevated CA-125 in our experience was 60% (15/9) at the start of gestation (any neoplasia or maliganacy was discarded) the levels rise untll week 10 to descend until the end of pregnancy.

Key words: Inhibin ß, CA-125, rFSH microdosing in PCOS.

Ernesto Gómez Arzapalo y V (1) "2" Clinica Florida Satelite. Victor Manuel Cerecedo Caballero"2" Alfredo Villacorta Argaez. 3" Hospital de Obstetricia y Pernatología Rio de la Loza Laboratorio – Métodos Diagnosticos

[email protected]

Introducción

El síndrome de ovarios poliquístico (OPQ) es una expresión metabólica presente durante la vida reproductiva, haciendo su aparición desde la época prepuberal. Estableciéndose los signos o síntomas objetivos y subjetivos.